HOTTIP Gene Summary [Human]
This gene produces a long RNA in antisense to the HOXA gene cluster. This transcript may regulate expression of HOXA genes in cis. This gene is upregulated in tumors and is implicated in the promotion of cell proliferation. [provided by RefSeq, Dec 2017]
Details
| Type | Long Non-Coding RNA |
| Official Symbol | HOTTIP |
| Official Name | HOXA distal transcript antisense RNA [Source:HGNC Symbol;Acc:HGNC:37461] |
| Ensembl ID | ENSG00000243766 |
| Bio databases IDs | |
| Aliases | HOXA distal transcript antisense RNA, HOXA cluster antisense RNA 6 (non-protein coding), HOXA transcript at the distal tip, HOXA13 antisense RNA 1 (non-protein coding) |
| Synonyms | Gm15053, HOXA13-AS1, HOXA-AS6, HOXA distal transcript antisense RNA, NCRNA00213 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HOTTIP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- miR-19b-3p (and other miRNAs w/seed GUGCAAA)
- miR-423-5p (and other miRNAs w/seed GAGGGGC)
- mir-150 (includes others)
- miR-744-5p (and other miRNAs w/seed GCGGGGC)
disease
- albuminuria
- epithelial cancer
- hypertension
- liver cancer
- insulin resistance
- pancreatic neoplasm
- pancreatic neoplasia
- chronic hepatitis B virus related liver cirrhosis
- major depression
- survival
role in cell
- proliferation
- apoptosis
- growth
- migration
- cell viability
- expression in
- phosphorylation in
- invasion by
- number
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown