Hottip Gene Summary [Mouse]
Involved in several processes, including hindlimb morphogenesis; neuromuscular process controlling posture; and post-anal tail morphogenesis. Acts upstream of or within neuromuscular process and skeletal muscle fiber development. Is expressed in several structures, including cartilage; limb; and limb bud. Orthologous to human HOTTIP (HOXA distal transcript antisense RNA). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Long Non-Coding RNA |
| Official Symbol | Hottip |
| Official Name | Hoxa distal transcript antisense RNA [Source:MGI Symbol;Acc:MGI:3642509] |
| Ensembl ID | ENSMUSG00000055408 |
| Bio databases IDs | |
| Aliases | Hoxa distal transcript antisense RNA |
| Synonyms | Gm15053, HOXA13-AS1, HOXA-AS6, HOXA distal transcript antisense RNA, NCRNA00213 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hottip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- miR-19b-3p (and other miRNAs w/seed GUGCAAA)
- miR-423-5p (and other miRNAs w/seed GAGGGGC)
- mir-150 (includes others)
- miR-744-5p (and other miRNAs w/seed GCGGGGC)
disease
- albuminuria
- epithelial cancer
- hypertension
- liver cancer
- insulin resistance
- pancreatic neoplasm
- pancreatic neoplasia
- chronic hepatitis B virus related liver cirrhosis
- major depression
- survival
role in cell
- proliferation
- apoptosis
- growth
- migration
- cell viability
- expression in
- phosphorylation in
- invasion by
- number
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown