APOBEC3D Gene Summary [Human]
This gene is a member of the cytidine deaminase gene family. It is one of a group of related genes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | APOBEC3D |
| Official Name | apolipoprotein B mRNA editing enzyme catalytic subunit 3D [Source:HGNC Symbol;Acc:HGNC:17354] |
| Ensembl ID | ENSG00000243811 |
| Bio databases IDs | |
| Aliases | apolipoprotein B mRNA editing enzyme catalytic subunit 3D |
| Synonyms | A3D, A3DE, APOBEC3DE, APOBEC3E, apolipoprotein B mRNA editing enzyme catalytic subunit 3D, ARP6 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human APOBEC3D often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytidine_deaminase-like
- APOBEC2
- APOBEC3
- Novel AID APOBEC clade 2
- APOBEC-like N-terminal domain
- Novel AID APOBEC clade 1
- APOBEC4-like -AID/APOBEC-deaminase
- APOBEC1
- APOBEC4
- Secreted Novel AID/APOBEC-like Deaminase 4
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic mRNA processing body
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human APOBEC3D gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA cytosine deamination
- negative regulation of retroviral genome replication
- innate immune response
- clearance of foreign intracellular DNA
- defense response to virus
- cytidine deamination
- cytidine to uridine editing
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytoplasmic mRNA processing body
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- RNA binding
- cytidine deaminase activity