RIPK2 Gene Summary [Human]
This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RIPK2 |
| Official Name | receptor interacting serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:10020] |
| Ensembl ID | ENSG00000104312 |
| Bio databases IDs | |
| Aliases | receptor interacting serine/threonine kinase 2 |
| Synonyms | 2210420D18RIK, 8Q21.3 RICK, CARD3, CARDIAK, CCK, D4Bwg0615e, GIG30, receptor interacting serine/threonine kinase 2, receptor-interacting serine-threonine kinase 2, receptor (TNFRSF)-interacting serine-threonine kinase 2, RICK, RIP2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RIPK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CARD domain binding
- LIM-domain binding
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protease binding
- ATP-binding domain
- Protein tyrosine and serine/threonine kinase
- protein binding activity, bridging
- protein binding
- receptor binding
- Protein kinase domain
- identical protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Caspase recruitment domain
- Protein Kinases, catalytic domain
- protein homodimerization
- Death Domain Superfamily of protein-protein interaction domains
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the RIPK2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- infection
- epithelial cancer
- obesity
- metastasis
- colorectal cancer
- reperfusion injury
- experimentally induced bacterial peritonitis
- pancreatic cancer
- nasopharyngeal carcinoma
role in cell
- activation in
- cell death
- binding in
- expression in
- survival
- quantity
- proliferation
- apoptosis
- differentiation
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytoskeleton
- Cytoplasm
- vesicles
- intercellular junctions
- cytoplasmic aggregates
- cytosol
- dense-core vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RIPK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein binding
- JNK cascade
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of interferon-alpha production
- inflammatory response
- activation of cysteine-type endopeptidase activity
- positive regulation of interferon-beta production
- apoptotic process
- positive regulation of interferon-gamma production
- positive regulation of protein ubiquitination
- positive regulation of tumor necrosis factor production
- positive regulation of chemokine production
- defense response to Gram-positive bacterium
- stress-activated MAPK cascade
- positive regulation of peptidyl-serine phosphorylation
- toll-like receptor 4 signaling pathway
- protein homooligomerization
- adaptive immune response
- positive regulation of immature T cell proliferation in thymus
- defense response to bacterium
- nucleotide-binding oligomerization domain containing 2 signaling pathway
- response to interleukin-18
- response to interleukin-12
- response to interleukin-1
- lipopolysaccharide-mediated signaling pathway
- positive regulation of interleukin-6 production
- positive regulation of stress-activated MAPK cascade
- positive regulation of CD4-positive, alpha-beta T cell proliferation
- positive regulation of T-helper 1 cell differentiation
- toll-like receptor 2 signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of transcription from RNA polymerase II promoter
- immature T cell proliferation in thymus
- positive regulation of macrophage cytokine production
- positive regulation of cytokine-mediated signaling pathway
- CD4-positive, alpha-beta T cell proliferation
- cytokine-mediated signaling pathway
- response to exogenous dsRNA
- nucleotide-binding oligomerization domain containing 1 signaling pathway
- positive regulation of peptidyl-tyrosine phosphorylation
- T cell receptor signaling pathway
- positive regulation of interleukin-2 production
- signal transduction
- I-kappaB kinase/NF-kappaB cascade
- ERK1 and ERK2 cascade
- positive regulation of interleukin-12 production
- cellular response to lipoteichoic acid
- innate immune response
- positive regulation of JNK cascade
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of apoptotic process
- positive regulation of T-helper 1 type immune response
- positive regulation of peptidyl-threonine phosphorylation
- cellular response to peptidoglycan
- cellular response to muramyl dipeptide
- positive regulation of interleukin-1 beta production
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
- cytosol
- vesicle
- endoplasmic reticulum
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein homodimerization activity
- protein binding
- non-membrane spanning protein tyrosine kinase activity
- signaling adaptor activity
- JUN kinase kinase kinase activity
- LIM domain binding
- CARD domain binding
- protein serine/threonine kinase activity
- receptor binding