HS3ST5 Gene Summary [Human]
HS3ST5 belongs to a group of heparan sulfate 3-O-sulfotransferases (EC 2.8.2.23) that transfer sulfate from 3-prime-phosphoadenosine 5-prime phosphosulfate (PAPS) to heparan sulfate and heparin (Mochizuki et al., 2003 [PubMed 12740361]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | HS3ST5 |
| Official Name | heparan sulfate-glucosamine 3-sulfotransferase 5 [Source:HGNC Symbol;Acc:HGNC:19419] |
| Ensembl ID | ENSG00000249853 |
| Bio databases IDs | |
| Aliases | heparan sulfate-glucosamine 3-sulfotransferase 5 |
| Synonyms | 3-OST-5, D930005L05RIK, Gm1151, heparan sulfate (glucosamine) 3-O-sulfotransferase 5, heparan sulfate-glucosamine 3-sulfotransferase 5, heparan sulphate (glucosamine) 3-O-sulphotransferase 5, heparan sulphate-glucosamine 3-sulphotransferase 5, HS3OST5, NBLA04021 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HS3ST5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- [heparan sulfate]-glucosamine 3-sulfotransferase 1
- Sulfotransferase domain
- enzyme
- protein binding
- Sulfotransferase family
Pathways
Biological processes and signaling networks where the HS3ST5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HS3ST5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heparan sulfate proteoglycan biosynthetic process, enzymatic modification
- regulation of viral entry into host cell
- negative regulation of coagulation
- protein sulfation
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
- 3'-phosphoadenosine 5'-phosphosulfate binding