PELP1 Gene Summary [Human]
This gene encodes a transcription factor which coactivates transcription of estrogen receptor responsive genes and corepresses genes activated by other hormone receptors or sequence-specific transcription factors. Expression of this gene is regulated by both members of the estrogen receptor family. This gene may be involved in the progression of several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Details
| Type | Protein Coding |
| Official Symbol | PELP1 |
| Official Name | proline, glutamate and leucine rich protein 1 [Source:HGNC Symbol;Acc:HGNC:30134] |
| Ensembl ID | ENSG00000141456 |
| Bio databases IDs | |
| Aliases | proline, glutamate and leucine rich protein 1 |
| Synonyms | 4930563C04RIK, MNAR, P160, Proline and Glutamic Acid-Rich Nuclear, proline, glutamate and leucine rich protein 1, proline, glutamic acid and leucine rich protein 1, RGD1306320 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PELP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NUC202 domain
- leucine rich domain
- LXXLL motif
- glutamate stretch region
- nuclear localization sequence
- rRNA processing/ribosome biogenesis
- chromatin binding
- protein binding
- glutamic acid-rich domain
- proline rich domain
- histone H1 binding domain
Pathways
Biological processes and signaling networks where the PELP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- hyperplasia
- tumorigenesis
- mammary intraepithelial neoplasia
- cutaneous melanoma
- cutaneous melanoma cancer
- atypical hyperplasia
role in cell
- apoptosis
- activation in
- binding in
- proliferation
- expression in
- phosphorylation in
- growth
- transactivation in
- cell cycle progression
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- granular components
- nucleoplasm
- nucleoli
- nuclear speckles
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PELP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rRNA processing
- positive regulation of transcription from RNA polymerase II promoter
- cellular response to estrogen stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- euchromatin
- cytoplasm
- nucleolus
- nucleoplasm
- MLL1 complex
Molecular Function
What the gene product does at the molecular level
- SUMO binding
- protein binding
- RNA binding
- chromatin binding