PVT1 Gene Summary [Human]
This gene represents a long non-coding RNA locus that has been identified as a candidate oncogene. Increased copy number and overexpression of this gene are associated with many types of cancers including breast and ovarian cancers, acute myeloid leukemia and Hodgkin lymphoma. Allelic variants of this gene are also associated with end-stage renal disease attributed to type 1 diabetes. Consistent with its association with various types of cancer, transcription of this gene is regulated by the tumor suppressor p53 through a canonical p53-binding site, and it has been implicated in regulating levels of the proto-oncogene MYC to promote tumorigenesis. [provided by RefSeq, Sep 2015]
Details
| Type | Long Non-Coding RNA |
| Official Symbol | PVT1 |
| Official Name | Pvt1 oncogene [Source:HGNC Symbol;Acc:HGNC:9709] |
| Ensembl ID | ENSG00000249859 |
| Bio databases IDs | |
| Aliases | Pvt1 oncogene, non-protein coding RNA 79, long intergenic non-protein coding RNA 79, MIR1204, MIR1205, MIR1206 and MIR1207 host gene, plasmacytoma variant translocation 1 |
| Synonyms | Ayu21-84Imeg, Gt(pU21)84Imeg, HSALNG0068477, LINC00079, linc-EFR3A-7, MIR1204HG, Mis-1, Mlvi-1, NCRNA00079, onco-lncRNA-100, plasmacytoma variant translocation 1, Pvt1 oncogene, TCONS 00015354, TP53LC09, XLOC 006922 |
| Species | Human, Homo sapiens |
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- single major depressive episode
- neoplasia
- metastasis
- epithelial cancer
- chronic kidney disease
- insulin-dependent diabetes mellitus
- multiple sclerosis
- renal cell carcinoma
- renal cell cancer
role in cell
- expression in
- migration
- apoptosis
- adhesion
- proliferation
- phosphorylation in
- binding in
- cell viability
- invasion by
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown