CHMP1B Gene Summary [Human]
CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | CHMP1B |
| Official Name | charged multivesicular body protein 1B [Source:HGNC Symbol;Acc:HGNC:24287] |
| Ensembl ID | ENSG00000255112 |
| Bio databases IDs | |
| Aliases | charged multivesicular body protein 1B |
| Synonyms | 2810405I11Rik, C10orf2, C18-ORF2, charged multivesicular body protein 1B, CHMP1.5, Chmp1b1, hVps46-2, LOC682926, Vps46-2, Vps46B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CHMP1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil domain
- protein domain specific binding
- enzyme
- protein binding
- identical protein binding
- acidic domain
- Snf7
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- perinuclear body
- Cytoplasm
- cellular membrane
- Nucleus
- endosomes
- midbody
- lysosome membrane
- endosomal membrane
- nuclear pores
- nucleoplasm
- autophagic vacuoles
- multivesicular bodies
- kinetochore microtubule
- kinetochores
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CHMP1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fission
- protein transport
- late endosome to vacuole transport
- nucleus organization
- cell division
- establishment of protein localization
- regulation of centrosome duplication
- non-lytic virus budding from plasma membrane
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- plasma membrane repair
- autophagy
- endosome transport via multivesicular body sorting pathway
- multivesicular body sorting pathway
- nuclear envelope reassembly
- mitotic metaphase plate congression
- vesicle fusion with vacuole
Cellular Component
Where in the cell the gene product is active
- ESCRT III complex
- kinetochore
- multivesicular body
- plasma membrane
- autophagic vacuole membrane
- lysosomal membrane
- nuclear pore
- nucleoplasm
- membrane coat
- extracellular vesicular exosome
- kinetochore microtubule
- cytosol
- endosome membrane
- midbody
- multivesicular body membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein domain specific binding
- protein binding