Chmp1b Gene Summary [Mouse]
Predicted to enable MIT domain binding activity and identical protein binding activity. Predicted to be involved in several processes, including midbody abscission; regulation of cell cycle process; and vacuolar transport. Predicted to be located in several cellular components, including bounding membrane of organelle; kinetochore microtubule; and midbody. Predicted to be part of ESCRT III complex; membrane coat; and nuclear pore. Predicted to be active in multivesicular body. Orthologous to human CHMP1B (charged multivesicular body protein 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chmp1b |
| Official Name | charged multivesicular body protein 1B [Source:MGI Symbol;Acc:MGI:1914314] |
| Ensembl ID | ENSMUSG00000109901 |
| Bio databases IDs | |
| Aliases | charged multivesicular body protein 1B |
| Synonyms | 2810405I11Rik, C10orf2, C18-ORF2, charged multivesicular body protein 1B, CHMP1.5, Chmp1b1, hVps46-2, LOC682926, Vps46-2, Vps46B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chmp1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil domain
- protein domain specific binding
- enzyme
- protein binding
- identical protein binding
- acidic domain
- Snf7
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- perinuclear body
- Cytoplasm
- cellular membrane
- Nucleus
- endosomes
- midbody
- lysosome membrane
- endosomal membrane
- nuclear pores
- nucleoplasm
- autophagic vacuoles
- multivesicular bodies
- kinetochore microtubule
- kinetochores
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chmp1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fission
- protein transport
- late endosome to vacuole transport
- nucleus organization
- cell division
- establishment of protein localization
- regulation of centrosome duplication
- non-lytic virus budding from plasma membrane
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- plasma membrane repair
- autophagy
- endosome transport via multivesicular body sorting pathway
- multivesicular body sorting pathway
- nuclear envelope reassembly
- mitotic metaphase plate congression
- vesicle fusion with vacuole
Cellular Component
Where in the cell the gene product is active
- ESCRT III complex
- kinetochore
- multivesicular body
- plasma membrane
- autophagic vacuole membrane
- lysosomal membrane
- nuclear pore
- nucleoplasm
- membrane coat
- extracellular vesicular exosome
- kinetochore microtubule
- cytosol
- endosome membrane
- midbody
- multivesicular body membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein domain specific binding
- protein binding