CHMP5 Gene Summary [Human]
CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | CHMP5 |
| Official Name | charged multivesicular body protein 5 [Source:HGNC Symbol;Acc:HGNC:26942] |
| Ensembl ID | ENSG00000086065 |
| Bio databases IDs | |
| Aliases | charged multivesicular body protein 5 |
| Synonyms | 2210412K09Rik, C9orf83, CGI-34, charged multivesicular body protein 5, HSPC177, PNAS-2, RGD1305968, SNF7DC2, Spike, Vps60 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CHMP5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PTZ00464
- Bcl-2 homology 3 domain
- coiled-coil domain
- protein binding
- Snf7
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- gastric epithelial cancer
- systemic lupus erythematosus
- gastric adenocarcinoma
- acute myeloid leukemia
- cardia bifida
regulated by
- cadmium chloride
- interferon alpha
- E3/ISG15
- mercuric chloride
- SB203580
role in cell
- apoptosis
- morphology
- function
- transmembrane potential
- quantity
- fusion
- organization
- response by
- autophagy by
- distribution
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- contractile rings
- midbody
- cytosol
- lysosome membrane
- nuclear pores
- autophagic vacuoles
- perinuclear vesicles
- multivesicular bodies
- kinetochore microtubule
- kinetochores
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CHMP5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fission
- protein transport
- non-lytic virus budding
- nucleus organization
- membrane budding
- erythrocyte differentiation
- non-lytic virus budding from plasma membrane
- regulation of centrosome duplication
- cellular response to lipopolysaccharide
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- plasma membrane repair
- autophagy
- multivesicular body sorting pathway
- cellular response to muramyl dipeptide
- nuclear envelope reassembly
- mitotic metaphase plate congression
- late endosome to vacuole transport via multivesicular body sorting pathway
- regulation of receptor recycling
- vesicle fusion with vacuole
Cellular Component
Where in the cell the gene product is active
- ESCRT III complex
- kinetochore
- multivesicular body
- autophagic vacuole membrane
- lysosomal membrane
- plasma membrane
- nuclear pore
- extracellular vesicular exosome
- kinetochore microtubule
- cytosol
- multivesicular body membrane
- midbody
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding