HCAR3 Gene Summary [Human]
Predicted to enable GTP binding activity and purinergic nucleotide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in cell junction. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | HCAR3 |
| Official Name | hydroxycarboxylic acid receptor 3 [Source:HGNC Symbol;Acc:HGNC:16824] |
| Ensembl ID | ENSG00000255398 |
| Bio databases IDs | |
| Aliases | hydroxycarboxylic acid receptor 3 |
| Synonyms | GPR109B, HCA3, HM74, hydroxycarboxylic acid receptor 3, PUMAG |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HCAR3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the HCAR3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- nicotinic acid
- PURT
disease
- stroke
- heart disease
- hypertriglyceridemia
- dyslipidemia
- peripheral arterial disease
- coronary artery disease
- mixed dyslipidemia
- severe hypertriglyceridemia
- plasma cell myeloma
- homozygous familial hypercholesterolemia
regulates
- cyclic AMP
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HCAR3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cell junction
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- nicotinic acid receptor activity