CARD18 Gene Summary [Human]
Enables CARD domain binding activity and caspase binding activity. Involved in inhibition of cysteine-type endopeptidase activity; negative regulation of interleukin-1 beta production; and negative regulation of protein binding activity. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CARD18 |
| Official Name | caspase recruitment domain family member 18 [Source:HGNC Symbol;Acc:HGNC:28861] |
| Ensembl ID | ENSG00000255501 |
| Bio databases IDs | |
| Aliases | caspase recruitment domain family member 18 |
| Synonyms | caspase recruitment domain family member 18, ICEBERG, pseudo-ICE, UNQ5804 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CARD18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CARD domain binding
- Caspase recruitment domain
- protease binding
- protein binding
- Death Domain Superfamily of protein-protein interaction domains
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CARD18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- negative regulation of interleukin-1 beta production
- regulation of apoptotic process
- negative regulation of protein binding
Cellular Component
Where in the cell the gene product is active
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- cysteine-type endopeptidase inhibitor activity
- CARD domain binding