RAB5A
RAB5A Gene Summary
Enables GDP binding activity; GTP binding activity; and GTPase activity. Involved in several processes, including amyloid-beta clearance by transcytosis; early endosome to late endosome transport; and regulation of exocytosis. Located in several cellular components, including cytoplasmic side of early endosome membrane; nucleoplasm; and terminal bouton. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RAB5A |
| Official Name | RAB5A, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9783] |
| Ensembl ID | ENSG00000144566 |
| Bio databases IDs | |
| Aliases | RAB5A, member RAS oncogene family, RAS-associated protein RAB5A |
| Synonyms | 2410015H04Rik,nnyRab5a,RAB5,RAB5A, member RAS oncogene family |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding domain
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- alpha helix
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- GTP binding
- small GTP-binding protein domain
- GTPase domain
- GDP binding
- guanyl nucleotide binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the RAB5A gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ITM2B
- OCRL
- FANCI
- CAV1
- DERL2
- EEA1
- SNX5
- CLCC1
- EGFR
- GDI2
disease
- plaque psoriasis
- schizophrenia
- Huntington disease
- systemic lupus erythematosus
- infection by Influenza A virus subtype H1N1
- infection by vesicular stomatitis virus
- infection by Semliki Forest virus
- infection by murine hepatitis virus
- infection by Dengue virus 2
regulated by
- EGFR
- PTEN
- lipopolysaccharide
- SORL1
- ACSL4
- FCGR2A
- ALS2
- Rn Tre
- p38 MAPK
- HGF
regulates
- CDH1
- APP
- AKT
- SMAD2
- EGFR
- RPS6
- HYAL1
- ATP6V1H
- phosphatidylinositol
- phosphatidylinositol-3-phosphate
role in cell
- activation in
- maturation
- expression in
- invasion by
- apoptosis
- proliferation
- migration
- cell death
- cell viability
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- synaptic vesicle membrane
- prostasome
- glutaminergic synapse
- endocytic vesicle membrane
- intracellular membrane-bounded organelle
- ruffle
- exocytic vesicle
- cell surface
- somatodendritic region
- perinuclear region
- actin cytoskeleton
- Plasma Membrane
- endosomes
- vesicles
- Golgi Apparatus
- microtubules
- lipid droplets
- cytoplasmic aggregates
- cytosol
- membrane ruffles
- plasma membrane extracellular face
- synaptic membrane
- endosomal membrane
- nucleoplasm
- zymogen granules
- synaptic vesicles
- recycling endosomes
- early endosomes
- cytoplasmic vesicles
- endocytotic vesicle
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
- membrane rafts
- pseudopodia
- perikaryon
- axons
- dendrites
- axon terminals
- sorting endosomes
- exosomes
- phagosomes
- detergent-soluble fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the RAB5A gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- endocytosis
- intracellular protein transport
- positive regulation of exocytosis
- regulation of filopodium assembly
- regulation of endosome size
- regulation of long-term neuronal synaptic plasticity
- early endosome to late endosome transport
- regulation of autophagic vacuole assembly
- phagocytosis
- regulation of synaptic vesicle exocytosis
- canonical Wnt receptor signaling pathway
- receptor internalization
CELLULAR COMPONENT
Where in the cell the gene product is active
- synaptic vesicle
- neuronal cell body
- nucleoplasm
- dendrite
- early endosome
- early phagosome
- clathrin-coated endocytic vesicle membrane
- extracellular vesicular exosome
- endosome
- terminal button
- intracellular membrane-bounded organelle
- actin cytoskeleton
- ruffle
- cytosol
- axon
- phagocytic vesicle
- axon terminus
- plasma membrane
- early endosome membrane
- melanosome
- cytoplasm
- membrane raft
- phagocytic vesicle membrane
- endomembrane system
- endosome membrane
- synaptic vesicle membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- small monomeric GTPase activity
- GDP binding