CARD8 Gene Summary [Human]
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
Details
| Type | Processed Transcript |
| Official Symbol | CARD8 |
| Official Name | caspase recruitment domain family member 8 [Source:HGNC Symbol;Acc:HGNC:17057] |
| Ensembl ID | ENSG00000105483 |
| Bio databases IDs | |
| Aliases | caspase recruitment domain family member 8 |
| Synonyms | CARDINAL, caspase recruitment domain family member 8, DACAR, DAKAR, LOC102723980, NDPP, NDPP1, TUCAN |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CARD8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CARD domain binding
- signaling receptor activity
- peptidase
- protein binding activity, bridging
- FIIND domain
- protein domain specific binding
- protein binding
- enzyme regulator activity
- protease activator
- Caspase recruitment domain
- Function to find
- endopeptidase
- protein homodimerization
- Death Domain Superfamily of protein-protein interaction domains
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome
- androgenic alopecia
- rheumatoid arthritis
- lupus cerebritis
- gout
- diabetic retinopathy
- inflammatory bowel disease type 30
- infection by Human enterovirus B
role in cell
- apoptosis
- cell death
- expression in
- binding in
- adhesion
- pyroptosis
- molecular cleavage in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CARD8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of interleukin-1 beta production
- regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of apoptotic process
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- negative regulation of NLRP3 inflammasome complex assembly
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- self proteolysis
- negative regulation of tumor necrosis factor-mediated signaling pathway
- apoptotic process
- defense response to virus
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- positive regulation of interleukin-1 beta production
- negative regulation of lipopolysaccharide-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- macromolecular complex
- NLRP3 inflammasome complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- NACHT domain binding
- peptidase activity
- CARD domain binding
- cysteine-type endopeptidase activator activity involved in apoptotic process