ZNF432 Gene Summary [Human]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZNF432 |
| Official Name | zinc finger protein 432 [Source:HGNC Symbol;Acc:HGNC:20810] |
| Ensembl ID | ENSG00000256087 |
| Bio databases IDs | |
| Aliases | zinc finger protein 432 |
| Synonyms | KIAA0798, zinc finger protein 432 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZNF432 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- krueppel associated box
- transcription regulator
- damaged DNA binding
- Zinc-finger double domain
- protein binding activity, bridging
- protein binding
- KRAB (Kruppel-associated box) domain -A box
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- PARP1
- talazoparib
regulates
role in cell
- formation
- formation in
- olaparib sensitivity
- talazoparib sensitivity
- non-homologous end joining in
- talazoparib resistance
- olaparib resistance
- initial DNA end resection in
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZNF432 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to DNA damage stimulus
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- protein binding, bridging
- damaged DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity