LINC-ROR Gene Summary [Human]
This gene produces a long non-coding RNA that regulates the reprogramming of pluripotent stem cells. This RNA suppresses induction of tumor protein p53 after DNA damage. It is thought to act as a sponge for microRNAs that regulate stem cell factors POU class 5 homeobox 1, Nanog, and SRY-box 2. This RNA may also have a extracellular role in modulating response to hypoxia in hepatocellular cancer cells. Expression of this transcript is associated with tumor progression and epithelial to mesenchymal transition and metastasis. [provided by RefSeq, Dec 2017]
Details
| Type | Long Non-Coding RNA |
| Official Symbol | LINC-ROR |
| Official Name | long intergenic non-protein coding RNA, regulator of reprogramming [Source:HGNC Symbol;Acc:HGNC:43773] |
| Ensembl ID | ENSG00000258609 |
| Bio databases IDs | |
| Aliases | long intergenic non-protein coding RNA, regulator of reprogramming |
| Synonyms | lincRNA-RoR, lincRNA-ST8SIA3, lncRNA ROR, long intergenic non-protein coding RNA, regulator of reprogramming, ROR |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LINC-ROR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal carcinoma
- colorectal carcinomagenesis
- organismal death
- ovarian cancer
- survival
- metastasis
- papillary thyroid carcinoma
- papillary thyroid cancer
regulated by
- crizotinib
role in cell
- expression in
- proliferation
- migration
- invasion by
- phosphorylation in
- colony formation by
- cell viability
- apoptosis
- activation in
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LINC-ROR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- stem cell maintenance
- negative regulation of gene silencing by miRNA