MSMB Gene Summary [Human]

The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
MSMB
Official Name
microseminoprotein beta [Source:HGNC Symbol;Acc:HGNC:7372]
Ensembl ID
ENSG00000263639
Bio databases IDs NCBI: 4477 Ensembl: ENSG00000263639
Aliases microseminoprotein beta, beta-microseminoprotein
Synonyms beta MICROSEMINOPROTEIN, beta-MSP, HPC13, IGBF, IMMUNOGLOBULIN binding FACTOR, microseminoprotein beta, microseminoprotein, beta, microseminoprotein β, microseminoprotein, β, MSP, MSPB, PIP, PN44, PRPS, PSP, PSP57, PSP-94, β MICROSEMINOPROTEIN, β-MSP
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MSMB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein binding
  • Beta-microseminoprotein (PSP-94)

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • COVID-19
  • epithelial cancer
  • cancer
  • neoplasia
  • prostatic carcinoma
  • prostate cancer
  • hereditary prostate cancer 13
  • stuttering
  • senile lentigo
  • eczema
regulated by
  • dihydrotestosterone
  • TGFB1
  • beta-estradiol
  • INPP4B
  • MYC
  • dexamethasone
  • diethylstilbestrol
  • AR
  • testosterone
  • medroxyprogesterone acetate
regulates
role in cell
  • proliferation
  • drug resistance

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • Nucleus
  • plasma

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human MSMB gene, providing context for its role in the cell.

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • extracellular space

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.