ANXA8 Gene Summary [Human]
This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ANXA8 |
| Official Name | annexin A8 [Source:HGNC Symbol;Acc:HGNC:546] |
| Ensembl ID | ENSG00000265190 |
| Bio databases IDs | |
| Aliases | annexin A8 |
| Synonyms | AC245041.3, annexin A8, ANX8, CH17 360D52, CH17-360D5.2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ANXA8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- binding protein
- phosphatidylinositol-3,4,5-triphosphate binding
- phosphatidylinositol-4,5-bisphosphate binding
- calcium ion binding
- calcium-dependent phospholipid binding
- Annexin
- protein binding
- phospholipase A2 inhibitor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ANXA8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endosome organization
- endosomal transport
- blood coagulation
- negative regulation of serine-type endopeptidase activity
- negative regulation of phospholipase A2 activity
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- cytoplasm
- sarcolemma
- vesicle membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4,5-trisphosphate binding
- actin filament binding
- phosphatidylinositol-4,5-bisphosphate binding
- phosphatidylserine binding
- protein binding
- calcium ion binding
- phosphatidylinositol-3,4-bisphosphate binding
- calcium-dependent phospholipid binding