STAM2 Gene Summary [Human]
The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | STAM2 |
| Official Name | signal transducing adaptor molecule 2 [Source:HGNC Symbol;Acc:HGNC:11358] |
| Ensembl ID | ENSG00000115145 |
| Bio databases IDs | |
| Aliases | signal transducing adaptor molecule 2, HSE1 homolog (S. cerevisiae) |
| Synonyms | 1200004O12Rik, 5730456G07Rik, Hbp, signal transducing adaptor molecule 2, signal transducing adaptor molecule (SH3 domain and ITAM motif) 2, STAM2A, STAM2B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STAM2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GAT_SF
- Ubiquitin-interacting motif
- hrs-binding domain
- Ubiquitin interaction motif
- ubiquitin binding domain
- VHS, ENTH and ANTH domain superfamily
- coiled-coil domain
- protein binding
- Domain present in VPS-27, Hrs and STAM
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neonatal late-onset sepsis
- metabolic syndrome X
role in cell
- cell viability
- quantity
- proliferation
- degranulation
- degradation in
- endocytosis by
- exocytosis by
- degranulation in
- macroautophagy in
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- intracellular membrane-bounded organelle
- cellular membrane
- endosomes
- cytosol
- nucleoplasm
- early endosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STAM2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- membrane fission
- signal transduction
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- endocytic vesicle
- cytoplasm
- intracellular membrane-bounded organelle
- ESCRT-0 complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin binding
- phosphatidylinositol binding