PKD1L3 Gene Summary [Human]
This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores.[provided by RefSeq, Apr 2009]
Details
| Type | Protein Coding |
| Official Symbol | PKD1L3 |
| Official Name | polycystin 1 like 3, transient receptor potential channel interacting [Source:HGNC Symbol;Acc:HGNC:21716] |
| Ensembl ID | ENSG00000277481 |
| Bio databases IDs | |
| Aliases | polycystin 1 like 3, transient receptor potential channel interacting |
| Synonyms | polycystic kidney disease 1 like 3, polycystin 1 like 3, transient receptor potential channel interacting |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PKD1L3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Family of unknown function (DUF5585)
- C-terminal domain of homeodomain 1
- ion channel
- taste receptor
- Polycystin domain
- PLAT
- Treacher Collins syndrome protein Treacle
- Domain of unknown function (DUF4045)
- ion channel binding
- extracellular loop
- N-terminal domain of transcription factor Specificity Proteins (SP) 1-4
- Polycystin cation channel
- AF-4 proto-oncoprotein N-terminal region
- Nucleoporin homology of Germinal-centre associated nuclear protein
- calcium activated cation channel
- Ion transport protein
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- protein binding
- Lipoxygenase homology 2 (beta barrel) domain
- cation transporter
- ligand-gated ion channel
- Lectin C-type domain
- GPCR proteolysis site, GPS, motif
- Metaviral_G glycoprotein
- Spt5 C-terminal nonapeptide repeat binding Spt4
- cation channel
Pathways
Biological processes and signaling networks where the PKD1L3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- prostate cancer
- coronary artery disease
- IgA nephropathy
- osteoarthritis
- pervasive developmental disorder
- myocardial infarction
- prostatic carcinoma
- pain
role in cell
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PKD1L3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- detection of mechanical stimulus
- cation transport
- sensory perception of sour taste
- cellular response to acidity
- calcium ion transmembrane transport
- detection of chemical stimulus involved in sensory perception of sour taste
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- receptor complex
- cation channel complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- sour taste receptor activity
- protein binding
- calcium channel activity
- cation channel activity
- cation transmembrane transporter activity
- carbohydrate binding