Cttnbp2 Gene Summary [Mouse]
Predicted to enable SH3 domain binding activity and cytoskeletal regulatory protein binding activity. Predicted to be involved in regulation of modification of postsynaptic actin cytoskeleton. Predicted to act upstream of or within actin cytoskeleton organization. Located in dendritic spine. Part of FAR/SIN/STRIPAK complex. Is active in glutamatergic synapse and postsynaptic actin cytoskeleton. Is expressed in brain; dorsal grey horn; glans of male genital tubercle; intestine smooth muscle circular layer; and limb. Orthologous to human CTTNBP2 (cortactin binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Cttnbp2 |
| Official Name | cortactin binding protein 2 [Source:MGI Symbol;Acc:MGI:1353467] |
| Ensembl ID | ENSMUSG00000000416 |
| Bio databases IDs | |
| Aliases | cortactin binding protein 2 |
| Synonyms | 3010022N24RIK, 4732477G22, 4732477G22Rik, 6430526E05, 9130022E09Rik, AU040881, C7orf8, Cbp90, cortactin binding protein 2, CORTBP2, mKIAA1758, ORF4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cttnbp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Coiled-coil region of CCDC155 or KASH
- Nuf2, DHR10-like domain
- Family of unknown function (DUF5585)
- Coiled-coil domain-containing protein 3
- Ankyrin repeats (many copies)
- Arginine and glutamate-rich 1
- F-type ATP synthase, membrane subunit b
- Ankyrin repeat
- Prefoldin subunit
- ClassIIa_HDAC_Gln-rich-N
- Family with sequence similarity 184, A and B
- Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
- Cortactin-binding protein-2
- bZIP
- ankyrin repeats
- SPEC
- polo kinase kinase
- TPR/MLP1/MLP2-like protein
- Tropomyosin like
- Ezrin/radixin/moesin, alpha-helical domain
- Domain of unknown function (DUF4618)
- ATP synthase, F0 subunit b
- Uso1 / p115 like vesicle tethering protein, C terminal region
- Ankyrin repeats (3 copies)
- protein binding
- cytoskeletal regulatory protein binding
- Ciliary rootlet component, centrosome cohesion
- SH3-domain binding
- flagellar export protein FliJ
- Apg6 coiled-coil region
- MAP7 (E-MAP-115) family
- prefoldin
- Transforming acidic coiled-coil-containing protein (TACC), C-terminal
- Domain of unknown function (DUF4200)
- Nnf1
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- major depression
- idiopathic femoral head osteonecrosis
- neuroticism
- juvenile rheumatoid arthritis
- neurotic disorder
regulated by
- 5-hydroxytryptamine
- DIO3
- lenalidomide
- IL4R
role in cell
- expression in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cytoskeleton
- actin cytoskeleton
- dendritic spines
- synaptic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cttnbp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of synapse organization
Cellular Component
Where in the cell the gene product is active
- cell cortex
- synaptic vesicle
- dendritic spine
Molecular Function
What the gene product does at the molecular level
- protein binding
- SH3 domain binding