Mei4 Gene Summary [Mouse]
Involved in meiotic DNA double-strand break formation. Acts upstream of or within homologous chromosome pairing at meiosis; oogenesis; and spermatogenesis. Located in lateral element. Is expressed in spermatocyte. Orthologous to human MEI4 (meiotic double-stranded break formation protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mei4 |
| Official Name | meiotic double-stranded break formation protein 4 [Source:MGI Symbol;Acc:MGI:1922283] |
| Ensembl ID | ENSMUSG00000043289 |
| Bio databases IDs | |
| Aliases | meiotic double-stranded break formation protein 4 |
| Synonyms | 4930486G11Rik, LOC682486, meiotic double-stranded break formation protein 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mei4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Meiosis-specific protein Mei4
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- synaptonemal complexes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mei4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oogenesis
- spermatogenesis
- DNA recombination
- synapsis
- meiotic DNA double-strand break formation
Cellular Component
Where in the cell the gene product is active
- lateral element
- chromosome
Molecular Function
What the gene product does at the molecular level
- protein binding