Adora3 Gene Summary [Mouse]
This gene encodes a transmembrane and immunoglobulin domain-containing protein. Alternative splicing results in multiple transcript variants, one of which shares its 3' terminal exon with that of the overlapping adenosine A3 receptor gene (GeneID:11542). [provided by RefSeq, Nov 2014]
Details
| Type | Protein Coding |
| Official Symbol | Adora3 |
| Official Name | adenosine A3 receptor [Source:MGI Symbol;Acc:MGI:104847] |
| Ensembl ID | ENSMUSG00000000562 |
| Bio databases IDs | |
| Aliases | adenosine A3 receptor |
| Synonyms | 1700001D09RIK, A3, A3AR, A(3)AR, A3R, AA3R, AD026, Ad3, ADENOSINE A3 receptor, ADORA, ARA3, Gpcr2, TGPCR1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adora3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled adenosine receptor
- transmembrane domain
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Adora3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- N6-(3-iodo-4-aminobenzyl)-adenosine-5'-N-methyluronamide
- MRS 1523
- N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine
- 5-(n-butyrylamino)-9-chloro-2-(2-furanyl)[1,2,4]triazolo-[1,5-c]quinazoline
- 5-N-ethylcarboxamido adenosine
- INTS3
- N-[3-(2-pyridinyl)isoquinolin-1-yl]-3,4-dimethylbenzamide
- TBC1D9B
- (R)-(-)-phenylisopropyl adenosine
- CGS-15943
disease
- coronary artery disease
- disorder of coronary artery
- acute myocardial infarction
- fibrosis
- ischemic cardiomyopathy
- neoplasia
- advanced hepatocellular carcinoma
- coronary disease
- precursor B-cell acute lymphoblastic leukemia
- hypoxia
role in cell
- cell death
- apoptosis
- proliferation
- activation in
- expression in
- phosphorylation in
- inhibition in
- quantity
- synthesis in
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- Extracellular Space
- cellular membrane
- presynaptic membrane
- neuromuscular junctions
- synaptosomes
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adora3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- adenosine receptor signaling pathway
- signal transduction
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of cell proliferation
- response to wounding
- regulation of heart contraction
- regulation of norepinephrine secretion
- activation of adenylate cyclase activity
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- dendrite
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled adenosine receptor activity