Ints3 Gene Summary [Mouse]
Predicted to be involved in several processes, including mitotic G2/M transition checkpoint; response to ionizing radiation; and snRNA processing. Predicted to be located in nucleus and site of double-strand break. Predicted to be part of SOSS complex and integrator complex. Predicted to be active in cytoplasm. Orthologous to human INTS3 (integrator complex subunit 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ints3 |
| Official Name | integrator complex subunit 3 [Source:MGI Symbol;Acc:MGI:2140050] |
| Ensembl ID | ENSMUSG00000027933 |
| Bio databases IDs | |
| Aliases | integrator complex subunit 3 |
| Synonyms | C1orf193, C1orf60, INT3, integrator complex subunit 3, RGD1304593, SOSS-A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ints3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Integrator complex subunit 3 N-terminal
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ints3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- snRNA processing
- regulation of transcription elongation from RNA polymerase II promoter
- double-strand break repair via homologous recombination
- response to DNA damage stimulus
- response to ionizing radiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- cytoplasm
- SOSS complex
- nucleoplasm
- integrator complex
Molecular Function
What the gene product does at the molecular level
- protein binding