Ncoa2

Enables several functions, including RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and transcription coactivator activity. Involved in circadian regulation of gene expression; locomotor rhythm; and regulation of primary metabolic process. Acts upstream of or within cellular response to Thyroglobulin triiodothyronine; regulation of transcription by RNA polymerase II; and response to progesterone. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; lung non-small cell carcinoma; and prostate adenocarcinoma. Orthologous to human NCOA2 (nuclear receptor coactivator 2). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ncoa2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Ncoa2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Ncoa2 gene, providing context for its role in the cell.