Cryba1 Gene Summary [Mouse]
Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta acidic group member, encodes two proteins (crystallin, beta A3 and crystallin, beta A1) from a single mRNA. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Details
| Type | Retained Intron |
| Official Symbol | Cryba1 |
| Official Name | crystallin, beta A1 [Source:MGI Symbol;Acc:MGI:88518] |
| Ensembl ID | ENSMUSG00000000724 |
| Bio databases IDs | |
| Aliases | crystallin, beta A1 |
| Synonyms | BA3/A1, BA3A1C, beta-A3, CCZS, Cryb, CRYB1, crystallin beta A1, crystallin, beta A1, crystallin β A1, crystallin, β A1, Crystallin β A3, CTRCT10, β-A3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cryba1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of eye lens
- greek key motif
- protein binding
- identical protein binding
- Beta/Gamma crystallin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- high myopia
- hereditary disorder
- congenital zonular cataract with sutural opacities 10
- cataract disease
- exfoliative glaucoma
- major depression
- multiple types cataract 10
- congenital cataract
role in cell
- apoptosis
- autophagy by
- phagocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cryba1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of ERK1 and ERK2 cascade
- regulation of autophagy
- phagocytosis
- positive regulation of anoikis
- negative regulation of TOR signaling cascade
- visual perception
- negative regulation of cytokine production
- lens development in camera-type eye
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of eye lens