Cryba1 Gene Summary [Rat]
Predicted to enable identical protein binding activity. Predicted to be a structural constituent of eye lens. Involved in several processes, including lens development in camera-type eye; negative regulation of intracellular signal transduction; and positive regulation of anoikis. Used to study cataract; microphthalmia; and retinal detachment. Biomarker of ocular hypertension. Human ortholog(s) of this gene implicated in cataract and cataract 10 multiple types. Orthologous to human CRYBA1 (crystallin beta A1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cryba1 |
| Official Name | crystallin, beta A1 [Source:RGD Symbol;Acc:2415] |
| Ensembl ID | ENSRNOG00000008700 |
| Bio databases IDs | |
| Aliases | crystallin, beta A1 |
| Synonyms | BA3/A1, BA3A1C, beta-A3, CCZS, Cryb, CRYB1, crystallin beta A1, crystallin, beta A1, crystallin β A1, crystallin, β A1, Crystallin β A3, CTRCT10, β-A3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cryba1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of eye lens
- greek key motif
- protein binding
- identical protein binding
- Beta/Gamma crystallin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- high myopia
- hereditary disorder
- congenital zonular cataract with sutural opacities 10
- cataract disease
- exfoliative glaucoma
- major depression
- multiple types cataract 10
- congenital cataract
role in cell
- apoptosis
- autophagy by
- phagocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cryba1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of ERK1 and ERK2 cascade
- regulation of autophagy
- phagocytosis
- positive regulation of anoikis
- negative regulation of TOR signaling cascade
- visual perception
- negative regulation of cytokine production
- lens development in camera-type eye
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of eye lens