Crybb1 Gene Summary [Mouse]
This gene encodes a member of the crystallin family of proteins that contribute to the transparency and refractive properties of the ocular lens. The encoded protein associates with other beta crystallin proteins to form dimers, tetramers and other higher-order complexes. This gene is located adjacent to a related crystallin gene on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Details
| Type | Protein Coding |
| Official Symbol | Crybb1 |
| Official Name | crystallin, beta B1 [Source:MGI Symbol;Acc:MGI:104992] |
| Ensembl ID | ENSMUSG00000029343 |
| Bio databases IDs | |
| Aliases | crystallin, beta B1 |
| Synonyms | 3110006K12Rik, BB1CRY, beta B1 CRYSTALLIN, CATCN3, CRYB1, CRYB11, crystallin beta B1, crystallin, beta B1, crystallin β B1, crystallin, β B1, CTRCT17, β B1 CRYSTALLIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Crybb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of eye lens
- Peptidase inhibitor family I36
- protein binding
- Beta/Gamma crystallin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive congenital nuclear cataract type 3
- nuclear cataract 17 with microcornea
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- high myopia
- congenital cataract
regulates
role in cell
- solubilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Crybb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- visual perception
- lens development in camera-type eye
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of eye lens