Chchd2 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor binding activity and sequence-specific DNA binding activity. Predicted to be involved in mitochondrion organization; positive regulation of transcription by RNA polymerase II; and regulation of cellular response to hypoxia. Located in mitochondrion. Is expressed in several structures, including cerebral cortex; diaphragm; gonad; head mesenchyme; and vertebral axis musculature. Human ortholog(s) of this gene implicated in Parkinson's disease 22. Orthologous to several human genes including CHCHD2 (coiled-coil-helix-coiled-coil-helix domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chchd2 |
| Official Name | coiled-coil-helix-coiled-coil-helix domain containing 2 [Source:MGI Symbol;Acc:MGI:1261428] |
| Ensembl ID | ENSMUSG00000070493 |
| Bio databases IDs | |
| Aliases | coiled-coil-helix-coiled-coil-helix domain containing 2 |
| Synonyms | AURA7, C7orf17, Chchd2l1, coiled-coil-helix-coiled-coil-helix domain containing 2, ETOHI6, MIX17B, MNRR1, NS2TP, PARK22 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chchd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription factor binding
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dementia
- glioblastoma cancer
- rheumatoid arthritis
- hepatic fibrosis
- organismal death
- autosomal dominant Parkinson disease type 22
- diet-induced nonalcoholic steatohepatitis
- glioblastoma
- Sengers syndrome
- nonalcoholic fatty liver disease
role in cell
- expression in
- phosphorylation in
- formation
- formation in
- differentiation
- number
- growth
- molecular cleavage in
- signaling in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- mitochondrial intermembrane space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chchd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to oxidative stress
- regulation of cellular response to hypoxia
- positive regulation of transcription from RNA polymerase II promoter
- regulation of generation of precursor metabolites and energy
- mitochondrion organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial intermembrane space
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein binding
- sequence-specific DNA binding