Pfn2 Gene Summary [Mouse]
Predicted to enable actin monomer binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including negative regulation of ruffle assembly; positive regulation of stress fiber assembly; and synapse organization. Acts upstream of or within positive regulation of actin filament polymerization and regulation of synaptic vesicle exocytosis. Is active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynapse. Is expressed in several structures, including central nervous system; cornea stroma; ganglia; hemolymphoid system gland; and tooth. Orthologous to human PFN2 (profilin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pfn2 |
| Official Name | profilin 2 [Source:MGI Symbol;Acc:MGI:97550] |
| Ensembl ID | ENSMUSG00000027805 |
| Bio databases IDs | |
| Aliases | profilin 2 |
| Synonyms | D3S1319E, DKFZP566N043, LOC100909840, PFL, Pfn, profilin 2, Profilin 2b, Profilin II |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pfn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PROF
- actin monomer binding
- phosphatidylinositol-4,5-bisphosphate binding
- actin binding
- Profilin
- enzyme
- protein binding
- ATPase
Pathways
Biological processes and signaling networks where the Pfn2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- androgenic alopecia
- schizophrenia
- diabetes mellitus
- Huntington disease
- non-small cell lung carcinoma
- Alzheimer disease
- facioscapulohumeral muscular dystrophy
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
role in cell
- assembly
- formation
- migration
- phagocytosis by
- growth
- quantity
- outgrowth
- loss
- length
- abnormal quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- presynaptic regions
- postsynaptic region
- vesicles
- cytosol
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pfn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of ATPase activity
- negative regulation of ruffle assembly
- regulation of actin filament polymerization
- negative regulation of actin filament polymerization
- positive regulation of stress fiber assembly
- positive regulation of actin filament polymerization
- regulation of synaptic vesicle exocytosis
- negative regulation of epithelial cell migration
- positive regulation of actin filament bundle assembly
- protein stabilization
- actin cytoskeleton organization
- positive regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- extracellular vesicular exosome
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- phosphatidylinositol-4,5-bisphosphate binding
- protein binding
- actin binding
- actin monomer binding