Mff Gene Summary [Mouse]
Predicted to enable GTPase binding activity and protein homodimerization activity. Involved in mitochondrial fission and protein targeting to mitochondrion. Located in mitochondrial outer membrane and peroxisome. Human ortholog(s) of this gene implicated in encephalopathy due to defective mitochondrial and peroxisomal fission 2. Orthologous to human MFF (mitochondrial fission factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mff |
| Official Name | mitochondrial fission factor [Source:MGI Symbol;Acc:MGI:1922984] |
| Ensembl ID | ENSMUSG00000026150 |
| Bio databases IDs | |
| Aliases | mitochondrial fission factor |
| Synonyms | 5230400G24Rik, C2orf33, EMPF2, GL004, LOC100911613, LOC102556337, mitochondrial fission factor, RGD1310230 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mff often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- Mitochondrial and peroxisomal fission factor Mff
- enzyme binding
- protein homodimerization
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- heart failure
- dilated cardiomyopathy
- chronic obstructive pulmonary disease
- encephalopathy due to defective mitochondrial and peroxisomal fission 2
- encephalopathy due to mitochondrial and peroxisomal fission defect
- exostoses
- Leigh syndrome
- organismal death
- astigmatism
role in cell
- expression in
- proliferation
- apoptosis
- fragmentation
- fragmentation in
- growth
- development
- tubulation
- density
- fission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic vesicle membrane
- Endoplasmic Reticulum
- Mitochondria
- mitochondrial membrane
- mitochondrial outer membrane
- synaptic vesicles
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mff gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of peroxisome organization
- peroxisome fission
- positive regulation of protein targeting to membrane
- positive regulation of release of cytochrome c from mitochondria
- mitochondrial fusion
- mitochondrial fragmentation involved in apoptotic process
- positive regulation of mitochondrial fission
- mitochondrion organization
- mitochondrial fission
- protein targeting to mitochondrion
- release of cytochrome c from mitochondria
- regulation of mitochondrion organization
Cellular Component
Where in the cell the gene product is active
- peroxisome
- mitochondrial membrane
- synaptic vesicle
- mitochondrion
- macromolecular complex
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein homodimerization activity
- protein binding