Cers4 Gene Summary [Mouse]
Enables sphingosine N-acyltransferase activity. Acts upstream of or within ceramide biosynthetic process. Located in endoplasmic reticulum. Is expressed in nervous system; nose; oral epithelium; and skin. Orthologous to human CERS4 (ceramide synthase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Cers4 |
| Official Name | ceramide synthase 4 [Source:MGI Symbol;Acc:MGI:1914510] |
| Ensembl ID | ENSMUSG00000008206 |
| Bio databases IDs | |
| Aliases | ceramide synthase 4 |
| Synonyms | 2900019C14RIK, Ceramidase 4, ceramide synthase 4, LASS4, Trh1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cers4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TLC domain
- transcription regulator
- sphingosine N-acyltransferase
- protein binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- alopecia
- gout
role in cell
- activation in
- migration
- expression in
- epithelial-mesenchymal transition
- doxorubicin resistance
- paclitaxel resistance
- tamoxifen resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cers4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ceramide biosynthetic process
- sphingolipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- sphingosine N-acyltransferase activity