Dusp14 Gene Summary [Mouse]
Predicted to enable phosphoprotein phosphatase activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human DUSP14 (dual specificity phosphatase 14). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dusp14 |
| Official Name | dual specificity phosphatase 14 [Source:MGI Symbol;Acc:MGI:1927168] |
| Ensembl ID | ENSMUSG00000018648 |
| Bio databases IDs | |
| Aliases | dual specificity phosphatase 14 |
| Synonyms | 1110014C10Rik, 2310042C07Rik, D11Ertd395e, dual specificity phosphatase 14, Dusp14l2, Dusp14 predicted, MKP6, MKP-L |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dusp14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dual specificity phosphatase, catalytic domain
- phosphatase
- protein binding
- PTP_DSP_cys
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- tuberculosis
- Huntington disease
role in cell
- proliferation
- expression in
- production in
- activation in
- phosphorylation in
- survival
- dephosphorylation in
- mitochondrial respiration in
- radiosensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dusp14 gene, providing context for its role in the cell.
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- protein tyrosine phosphatase activity
- MAP kinase tyrosine/serine/threonine phosphatase activity
- myosin phosphatase activity