Chordc1 Gene Summary [Mouse]
Enables ADP binding activity; ATP binding activity; and zinc ion binding activity. Involved in several processes, including chaperone-mediated protein folding; negative regulation of Rho-dependent protein serine/threonine kinase activity; and regulation of centrosome duplication. Is expressed in brain; olfactory epithelium; trigeminal ganglion; and vomeronasal organ. Used to study chronic myeloid leukemia. Orthologous to human CHORDC1 (cysteine and histidine rich domain containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chordc1 |
| Official Name | cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1 [Source:MGI Symbol;Acc:MGI:1914167] |
| Ensembl ID | ENSMUSG00000001774 |
| Bio databases IDs | |
| Aliases | cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1 |
| Synonyms | 1110001O09Rik, CHP-1, cysteine and histidine rich domain containing 1, morgana |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chordc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CS domain
- zinc ion binding
- ADP binding
- alpha-crystallin Hsps/p23-like
- heat shock protein binding
- ATP binding
- CHORD
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- myeloproliferative disorder
- peripheral arterial disease
- infection by HIV-1
regulates
- HBsAg
- ROCK
role in cell
- expression in
- replication in
- amplification in
- hyperactivation in
- duplication
- amplification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chordc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of centrosome duplication
- centrosome duplication
- regulation of cellular response to heat
- chaperone-mediated protein folding
Molecular Function
What the gene product does at the molecular level
- ATP binding
- zinc ion binding
- protein binding
- Hsp90 protein binding
- ADP binding