Rmnd5a Gene Summary [Mouse]
Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein polyubiquitination. Predicted to be located in nucleoplasm. Predicted to be part of GID complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human RMND5A (required for meiotic nuclear division 5 homolog A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rmnd5a |
| Official Name | required for meiotic nuclear division 5 homolog A [Source:MGI Symbol;Acc:MGI:1915727] |
| Ensembl ID | ENSMUSG00000002222 |
| Bio databases IDs | |
| Aliases | required for meiotic nuclear division 5 homolog A |
| Synonyms | 1110007A06Rik, CTLH, GID2, GID2A, MTA.D02.090, p44CTLH, required for meiotic nuclear division 5 homolog A, RGD1309766, RMD5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rmnd5a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CTLH/CRA C-terminal to LisH motif domain
- RING-type zinc-finger
- CT11-RanBPM
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- C-terminal to LisH motif
- enzyme
- protein binding
- LisH
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rmnd5a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- protein polyubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- cytoplasm
- GID complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- metal ion binding