RMND5A Gene Summary [Human]
Predicted to enable metal ion binding activity and ubiquitin protein ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein polyubiquitination. Located in cytoplasm and nucleoplasm. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RMND5A |
| Official Name | required for meiotic nuclear division 5 homolog A [Source:HGNC Symbol;Acc:HGNC:25850] |
| Ensembl ID | ENSG00000153561 |
| Bio databases IDs | |
| Aliases | required for meiotic nuclear division 5 homolog A, GID complex subunit 2 homolog A, 44-kD protein coding for CTLH motif |
| Synonyms | 1110007A06Rik, CTLH, GID2, GID2A, MTA.D02.090, p44CTLH, required for meiotic nuclear division 5 homolog A, RGD1309766, RMD5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RMND5A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CTLH/CRA C-terminal to LisH motif domain
- RING-type zinc-finger
- CT11-RanBPM
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- C-terminal to LisH motif
- enzyme
- protein binding
- LisH
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RMND5A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- protein polyubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- cytoplasm
- GID complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- metal ion binding