Atg4d Gene Summary [Mouse]
Predicted to enable cysteine-type endopeptidase activity; cysteine-type exopeptidase activity; and protein-phosphatidylethanolamide deconjugating activity. Involved in protein delipidation. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human ATG4D (autophagy related 4D cysteine peptidase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atg4d |
| Official Name | autophagy related 4D, cysteine peptidase [Source:MGI Symbol;Acc:MGI:2444308] |
| Ensembl ID | ENSMUSG00000002820 |
| Bio databases IDs | |
| Aliases | autophagy related 4D, cysteine peptidase |
| Synonyms | 9830134P12Rik, APG4-D, Atg4dl, AUTL4, Autophagin-4, autophagy related 4D cysteine peptidase, autophagy related 4D, cysteine peptidase, HsAPG4D |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atg4d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine-type peptidase
- peptidase
- Peptidase family C54
- exopeptidase
Pathways
Biological processes and signaling networks where the Atg4d gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atg4d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization to pre-autophagosomal structure
- protein transport
- macromitophagy
- C-terminal protein lipidation
- protein delipidation
- autophagic vacuole assembly
- piecemeal microautophagy of nucleus
- autophagy
- apoptotic process
- proteolysis
- protein processing
- aggrephagy
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- cytoplasm
- mitochondrion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cysteine-type endopeptidase activity
- cysteine-type peptidase activity
- APG8-specific protease activity