Gopc Gene Summary [Mouse]
Enables GTPase regulator activity; frizzled binding activity; and protein homodimerization activity. Acts upstream of or within spermatid nucleus differentiation. Located in Golgi apparatus; plasma membrane; and synapse. Is expressed in genitourinary system and tongue. Used to study azoospermia. Orthologous to human GOPC (golgi associated PDZ and coiled-coil motif containing). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gopc |
| Official Name | golgi associated PDZ and coiled-coil motif containing [Source:MGI Symbol;Acc:MGI:2149946] |
| Ensembl ID | ENSMUSG00000019861 |
| Bio databases IDs | |
| Aliases | golgi associated PDZ and coiled-coil motif containing |
| Synonyms | 2210402P09Rik, AI844555, CAL, dJ94G16.2, FIG, golgi associated PDZ and coiled-coil motif containing, GOPC1, NPIST, PIST |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gopc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- GTPase regulator
- frizzled binding
- canonical PDZ domain
- coiled-coil domain
- protein binding
- PDZ domain
- identical protein binding
- syntaxin binding
- PDZ-domain binding
- protein homodimerization
- ion channel binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypocalcemia
- hyperphosphatemia
role in cell
- activation in
- expression in
- differentiation
- replication in
- quantity
- fragmentation
- autophagy by
- degradation in
- autophagy in
- retention in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- plasma membrane/trans-Golgi network fraction
- membrane fraction
- cell pole
- intracellular space
- perinuclear region
- cellular membrane
- Plasma Membrane
- vesicles
- Golgi Apparatus
- ER-to-Golgi intermediate compartment
- cytosol
- Golgi membrane
- trans face of the Golgi apparatus
- lysosome membrane
- spindle pole
- neurites
- synaptosomes
- synapse
- perikaryon
- dendrites
- postsynaptic density
- Golgi vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gopc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of anion channel activity
- ER to Golgi vesicle-mediated transport
- negative regulation of protein localization at cell surface
- apical protein localization
- protein transport
- Golgi to plasma membrane transport
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- dendrite
- cytoplasm
- trans-Golgi network transport vesicle
- membrane
- Golgi-associated vesicle membrane
- Golgi apparatus
- macromolecular complex
- Golgi membrane
- lysosomal membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- ion channel binding