Prpf40a Gene Summary [Mouse]

Enables proline-rich region binding activity. Predicted to be involved in several processes, including mRNA splicing, via spliceosome; regulation of cell shape; and regulation of cytokinesis. Located in nuclear matrix. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human PRPF40A (pre-mRNA processing factor 40 homolog A). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Prpf40a
Official Name
pre-mRNA processing factor 40A [Source:MGI Symbol;Acc:MGI:1860512]
Ensembl ID
ENSMUSG00000061136
Bio databases IDs NCBI: 56194 Ensembl: ENSMUSG00000061136
Aliases pre-mRNA processing factor 40A
Synonyms 2810012K09Rik, FBP-11, FLAF1, Fnbp11, FNBP3, HIP-10, HYPA, NY-REN-6, pre-mRNA processing factor 40A, pre-mRNA processing factor 40 homolog A, Prp40
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prpf40a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • FF domain
  • Domain with 2 conserved Trp (W) residues
  • Contains two conserved F residues
  • WW
  • protein binding
  • WW domain

Pathways

Biological processes and signaling networks where the Prpf40a gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • non-insulin-dependent diabetes mellitus
  • memory deficits
regulated by
regulates
role in cell
  • alternative splicing in
  • organization
  • cytokinesis in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • Cytoplasm
  • spliceosomes
  • nucleoplasm
  • nuclear speckles
  • nuclear matrix

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Prpf40a gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • regulation of cell shape
  • cell division
  • nuclear mRNA cis splicing, via spliceosome
  • cytoskeleton organization
  • regulation of cytokinesis
  • cell migration
  • nuclear mRNA splicing, via spliceosome

Cellular Component

Where in the cell the gene product is active
  • nuclear speck
  • membrane
  • nuclear matrix
  • U2-type prespliceosome
  • U1 snRNP
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • RNA binding
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.