St8sia6 Gene Summary [Mouse]
Enables sialyltransferase activity. Involved in ganglioside biosynthetic process; glycoprotein metabolic process; and oligosaccharide metabolic process. Acts upstream of or within several processes, including blastocyst hatching; glycolipid biosynthetic process; and protein O-linked glycosylation. Predicted to be located in membrane. Is expressed in several structures, including early conceptus; genitourinary system; hindgut diverticulum; nasal cavity epithelium; and notochord. Orthologous to human ST8SIA6 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | St8sia6 |
| Official Name | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 [Source:MGI Symbol;Acc:MGI:2386797] |
| Ensembl ID | ENSMUSG00000003418 |
| Bio databases IDs | |
| Aliases | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 |
| Synonyms | 1700007J08RIK, AI314453, AI875066, SIA8F, SIAT8-F, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6, ST8SIA-VI, ST8 α-N-acetyl-neuraminide α-2,8-sialyltransferase 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse St8sia6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyltransferase family 29 (sialyltransferase)
- glycosyltransferase family 29
- alpha-N-acetylneuraminate alpha-2,8-sialyltransferase
- sialyltransferase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse St8sia6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein O-linked glycosylation
- glycoprotein metabolic process
- carbohydrate biosynthetic process
- N-glycan processing
- blastocyst hatching
- protein glycosylation
- glycolipid biosynthetic process
- oligosaccharide metabolic process
- ganglioside biosynthetic process
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- sialyltransferase activity
- alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity