Nkap Gene Summary [Mouse]
Enables chromatin DNA binding activity. Acts upstream of or within hemopoiesis; negative regulation of transcription by RNA polymerase II; and somatic stem cell population maintenance. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Orthologous to human NKAP (NFKB activating protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nkap |
| Official Name | NFKB activating protein [Source:MGI Symbol;Acc:MGI:1914300] |
| Ensembl ID | ENSMUSG00000016409 |
| Bio databases IDs | |
| Aliases | NFKB activating protein |
| Synonyms | 2610020O08RIK, MRXSHD, NFKB activating protein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nkap often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- NF-kappa-B-activating protein C-terminal domain
- mRNA binding
- chromatin binding
- protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Hackman-Di Donato type syndromic X-linked mental retardation
role in cell
- expression in
- proliferation
- cell death
- binding in
- differentiation
- binding
- erastin sensitivity
- iFSP1 sensitivity
- Clathrin mediated endocytosis by
- erastin resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nkap gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- Notch signaling pathway
- negative regulation of transcription, DNA-dependent
- T cell differentiation in thymus
- somatic stem cell maintenance
- hemopoietic stem cell proliferation
- granulocyte differentiation
- positive regulation of alpha-beta T cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- protein binding
- RNA binding
- mRNA binding
- chromatin binding
- binding, bridging