Mmp14 Gene Summary [Mouse]
This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein exhibit craniofacial dysmorphism, arthritis, osteopenia, dwarfism, and fibrosis of soft tissues. [provided by RefSeq, Feb 2016]
Details
| Type | Protein Coding |
| Official Symbol | Mmp14 |
| Official Name | matrix metallopeptidase 14 (membrane-inserted) [Source:MGI Symbol;Acc:MGI:101900] |
| Ensembl ID | ENSMUSG00000000957 |
| Bio databases IDs | |
| Aliases | matrix metallopeptidase 14 (membrane-inserted) |
| Synonyms | matrix metallopeptidase 14, matrix metallopeptidase 14 (membrane-inserted), MMP-X1, MT1-MMP, MT-MMP, MT-MMP-1, sabe, WNCHRS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mmp14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hemopexin-like repeats
- hemopexin C-terminal domain
- blades of the PEX domain
- hemopexin domain
- peptidase
- O-linked glycosylation site
- signal peptide
- Zinc-dependent metalloprotease
- Putative peptidoglycan binding domain
- zinc ion binding
- cytoplasmic domain
- furin cleavage consensus sequence
- aminopeptidase
- Src phosphorylation site
- fibronectin-like domain
- Matrixin
- metalloexopeptidase
- catalytic domain
- HX
- linker domain
- protein binding
- ZnMc
- endopeptidase
- serine endopeptidase
- integrin binding
- transmembrane domain
- hinge domain
- active site
- cytosolic tail domain
- pro domain
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Mmp14 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Axonal Guidance Signaling
- Bladder Cancer Signaling
- Colorectal Cancer Metastasis Signaling
- Ephrin A Signaling
- Estrogen Receptor Signaling
- FAK Signaling
- Granulocyte Adhesion and Diapedesis
- HIF1α Signaling
- Inhibition of Matrix Metalloproteases
- Leukocyte Extravasation Signaling
- Molecular Mechanisms of Cancer
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- cutaneous melanoma
- non-insulin-dependent diabetes mellitus
- epithelial cancer
- cancer
- fibrosis
- breast carcinoma
- breast cancer
- diabetes mellitus
role in cell
- phosphorylation in
- activation in
- apoptosis
- expression in
- necrosis
- recruitment
- formation
- formation in
- degradation in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma membrane fraction
- Golgi lumen
- F-actin structure
- intermediate filament cytoskeleton
- Cytoplasm
- invadopodia
- cell-matrix contacts
- cell surface
- cell periphery
- intracellular space
- apical compartment
- membrane surface
- cellular membrane
- focal adhesions
- podosomes
- Nucleus
- Plasma Membrane
- endosomes
- vesicles
- centrosome
- Golgi Apparatus
- cell-cell contacts
- granules
- cytosol
- membrane ruffles
- caveolae
- Golgi membrane
- perinuclear space
- early endosomes
- late endosomes
- cytoplasmic vesicles
- lateral cell-cell contacts
- brush border
- clathrin-coated pits
- cellular protrusions
- membrane processes
- filopodia
- cell membrane leading edge
- plasma
- lamellipodia
- macropinosomes
- centrosomal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mmp14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- head development
- response to estrogen stimulus
- male gonad development
- craniofacial suture morphogenesis
- branching morphogenesis of a tube
- negative regulation of Notch signaling pathway
- response to mechanical stimulus
- zymogen activation
- response to oxidative stress
- positive regulation of cell growth
- response to hypoxia
- skeletal system development
- angiogenesis
- positive regulation of myotube differentiation
- positive regulation of protein processing
- lung development
- astrocyte cell migration
- protein catabolic process
- extracellular matrix disassembly
- embryonic cranial skeleton morphogenesis
- response to organic cyclic compound
- positive regulation of B cell differentiation
- ovarian follicle development
- tissue remodeling
- negative regulation of focal adhesion assembly
- cell motility
- proteolysis
- extracellular matrix organization
- endothelial cell proliferation
- endodermal cell differentiation
- endochondral ossification
- chondrocyte proliferation
- protein processing
- collagen catabolic process
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- macropinosome
- Golgi lumen
- plasma membrane
- nucleus
- extracellular space
- intermediate filament cytoskeleton
- focal adhesion
- melanosome
- cytoplasm
- cytosol
- cytoplasmic vesicle
- extracellular matrix
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- serine-type endopeptidase activity
- endopeptidase activity
- metalloaminopeptidase activity
- integrin binding
- metalloendopeptidase activity