Traf2 Gene Summary [Mouse]
Enables CD40 receptor binding activity; signaling adaptor activity; and ubiquitin protein ligase activity. Involved in several processes, including cytokine-mediated signaling pathway; positive regulation of signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including canonical NF-kappaB signal transduction; cellular response to nitric oxide; and regulation of intracellular signal transduction. Located in several cellular components, including cytoplasmic side of plasma membrane; membrane raft; and vesicle membrane. Part of CD40 receptor complex and IRE1-TRAF2-ASK1 complex. Is expressed in several structures, including genitourinary system; liver; lower jaw tooth; and mandibular process. Orthologous to human TRAF2 (TNF receptor associated factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Traf2 |
| Official Name | TNF receptor-associated factor 2 [Source:MGI Symbol;Acc:MGI:101835] |
| Ensembl ID | ENSMUSG00000026942 |
| Bio databases IDs | |
| Aliases | TNF receptor-associated factor 2 |
| Synonyms | MGC:45012, RNF117, TNF receptor-associated factor 2, TRAP, TRAP3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Traf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TNF receptor-associated factor BIRC3 binding domain
- cytokine binding
- protein binding activity, bridging
- coiled-coil domain
- enzyme
- identical protein binding
- effector domain
- ZAS domain
- TRAF-type zinc finger
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin protein ligase binding
- sphingolipid binding
- protein kinase binding
- MATH
- tumor necrosis factor receptor binding
- ubiquitin protein ligase activity
- protein phosphatase binding
- TRAF-N subdomain
- enzyme binding
- protein binding
- TRAF domain
- CD40 receptor binding
- binding protein
- ubiquitin-protein transferase activity
- WKI motif
- zinc finger domain
- TRAF-C subdomain
- Zinc finger, C3HC4 type (RING finger)
Pathways
Biological processes and signaling networks where the Traf2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 4-1BB Signaling in T Lymphocytes
- Acute Phase Response Signaling
- April Mediated Signaling
- B Cell Activating Factor Signaling
- CD27 Signaling in Lymphocytes
- CD40 Signaling
- Endoplasmic Reticulum Stress Pathway
- Glucocorticoid Receptor Signaling
- IL-6 Signaling
- Induction of Apoptosis by HIV1
- Lymphotoxin β Receptor Signaling
- Myc Mediated Apoptosis Signaling
- NF-κB Activation by Viruses
- NF-κB Signaling
- p38 MAPK Signaling
- RANK Signaling in Osteoclasts
- Role of RIG1-like Receptors in Antiviral Innate Immunity
- Small Cell Lung Cancer Signaling
- TNFR1 Signaling
- TNFR2 Signaling
- TWEAK Signaling
- Unfolded protein response
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart disease
- neoplasia
- inflammatory disorder
- splenomegaly
- liver cancer
- epithelial cancer
- lymphadenopathy
- organismal death
- cachexia
- colitis
role in cell
- activation in
- growth
- production in
- expression in
- activation
- migration
- invasion by
- cell death
- response
- necrosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- raft fractions
- soluble fraction
- insoluble fractions
- cell surface
- perinuclear region
- cellular membrane
- cell cortex
- Nucleus
- Plasma Membrane
- vesicles
- cytoplasmic aggregates
- cytosol
- cytoplasmic face of plasma membrane
- vesicle membrane
- endoplasmic reticulum membrane
- nucleoplasm
- perinuclear vesicles
- stress granule
- membrane rafts
- detergent-soluble fraction
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Traf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of JUN kinase activity
- negative regulation of glial cell apoptotic process
- signal transduction involved in regulation of gene expression
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of NF-kappaB transcription factor activity
- programmed necrotic cell death
- regulation of immunoglobulin production
- cellular response to nitric oxide
- positive regulation of interleukin-2 production
- protein autoubiquitination
- macromolecular complex assembly
- signal transduction
- protein catabolic process
- NIK/NF-kappaB cascade
- regulation of protein complex assembly
- regulation of apoptotic process
- regulation of JNK cascade
- tumor necrosis factor-mediated signaling pathway
- innate immune response
- mRNA stabilization
- positive regulation of T cell cytokine production
- protein K63-linked ubiquitination
- positive regulation of extrinsic apoptotic signaling pathway
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- TRAF2-GSTP1 complex
- ubiquitin ligase complex
- cytoplasm
- vesicle membrane
- cell cortex
- membrane raft
- cytosol
- CD40 receptor complex
- internal side of plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- zinc ion binding
- protein phosphatase binding
- signaling adaptor activity
- CD40 receptor binding
- tumor necrosis factor receptor binding
- sphingolipid binding
- ubiquitin-protein ligase activity
- ubiquitin protein ligase binding
- protein binding
- tumor necrosis factor binding
- thioesterase binding
- mitogen-activated protein kinase kinase kinase binding
- protein binding, bridging
- binding, bridging
- enzyme binding