Insig2 Gene Summary [Mouse]
Predicted to enable oxysterol binding activity and protein sequestering activity. Acts upstream of or within several processes, including cholesterol biosynthetic process; ear morphogenesis; and negative regulation of lipid biosynthetic process. Predicted to be part of SREBP-SCAP-Insig complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in central nervous system; jaw bone; and retina. Orthologous to human INSIG2 (insulin induced gene 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Insig2 |
| Official Name | insulin induced gene 2 [Source:MGI Symbol;Acc:MGI:1920249] |
| Ensembl ID | ENSMUSG00000003721 |
| Bio databases IDs | |
| Aliases | insulin induced gene 2 |
| Synonyms | 2900053I11Rik, C730043J18Rik, insulin induced gene 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Insig2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- oxysterol binding
- Insulin-induced protein (INSIG)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cleft palate syndrome
- gout
- hepatic steatosis
- runting
- cleft face
- lipidosis
- hyperlipidemia
- metabolic disorder
- hypercholesterolemia
role in cell
- expression in
- activation in
- degradation in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Insig2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to insulin stimulus
- negative regulation of fatty acid biosynthetic process
- cranial suture morphogenesis
- SREBP-mediated signaling pathway
- palate development
- inner ear morphogenesis
- cholesterol biosynthetic process
- middle ear morphogenesis
- triglyceride metabolic process
- negative regulation of steroid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- SREBP-SCAP-Insig complex
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- oxysterol binding