Atf4 Gene Summary [Mouse]
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding protein binding activity; and promoter-specific chromatin binding activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including cellular response to leucine starvation; intracellular signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including gluconeogenesis; positive regulation of sodium-dependent phosphate transport; and positive regulation of vascular associated smooth muscle cell apoptotic process. Located in cytoplasm and nucleus. Part of ATF1-ATF4 transcription factor complex and ATF4-CREB1 transcription factor complex. Is expressed in several structures, including central nervous system; embryo ectoderm; eye; genitourinary system; and long bone. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human ATF4 (activating transcription factor 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atf4 |
| Official Name | activating transcription factor 4 [Source:MGI Symbol;Acc:MGI:88096] |
| Ensembl ID | ENSMUSG00000042406 |
| Bio databases IDs | |
| Aliases | activating transcription factor 4 |
| Synonyms | activating transcription factor 4, C/ATF, CREB-2, TAXREB67, TXREB |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atf4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- cAMP response element binding protein binding
- transcription activation domain
- transcription factor binding
- leucine zipper domain
- chromatin binding
- identical protein binding
- bZIP domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- basic domain
- bZIP
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- protein kinase binding
- DNA binding domain
- nucleic acid binding
- LRR-domain binding
- Basic region leucine zipper
- protein binding
- sequence-specific DNA binding
- DNA binding
- basic amino acid motif
- double-stranded DNA binding
- transcription factor activity
- protein heterodimerization
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the Atf4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- ATM Signaling
- Calcium Signaling
- Corticotropin Releasing Hormone Signaling
- Dendritic Cell Maturation
- Docosahexaenoic Acid (DHA) Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- Endoplasmic Reticulum Stress Pathway
- ERK5 Signaling
- Estrogen-Dependent Breast Cancer Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- FGF Signaling
- Gαs Signaling
- Hypoxia Signaling in the Cardiovascular System
- IL-10 Signaling
- Melanocyte Development and Pigmentation Signaling
- Neurotrophin/TRK Signaling
- NGF Signaling
- P2Y Purinergic Receptor Signaling Pathway
- Prostate Cancer Signaling
- Protein Kinase A Signaling
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Synaptic Long Term Potentiation
- Unfolded protein response
- Wnt/Ca+ pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- eyelids fail to open
- anemia
- osteoarthritis
- rheumatoid arthritis
- aphakia
- Parkinson disease
- microphthalmia
- hypoplasia
- glioblastoma
role in cell
- production in
- proliferation
- expression in
- growth
- phosphorylation in
- apoptosis
- number
- cell death
- accumulation in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cell borders
- perinuclear region
- centrosome
- cytosol
- nucleoplasm
- neurites
- chromatin
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atf4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lens fiber cell morphogenesis
- positive regulation of sodium-dependent phosphate transport
- embryonic hemopoiesis
- cellular response to amino acid starvation
- transcription from RNA polymerase II promoter
- negative regulation of potassium ion transport
- positive regulation of transcription from RNA polymerase II promoter
- response to toxin
- positive regulation of neuron apoptotic process
- gamma-aminobutyric acid signaling pathway
- regulation of osteoblast differentiation
- positive regulation of transcription from RNA polymerase I promoter
- negative regulation of transcription from RNA polymerase II promoter
- circadian regulation of gene expression
- positive regulation of transcription, DNA-dependent
- endoplasmic reticulum unfolded protein response
- regulation of synaptic plasticity
- cellular response to UV
- L-asparagine metabolic process
- positive regulation of biomineral tissue development
- cellular response to hypoxia
- positive regulation vascular endothelial growth factor production
- mRNA transcription from RNA polymerase II promoter
- gluconeogenesis
- bone mineralization
- neuron differentiation
- regulation of transcription, DNA-dependent
- cellular response to glucose starvation
- cellular calcium ion homeostasis
- regulation of transcription from RNA polymerase II promoter
- positive regulation of gene expression
- positive regulation of apoptotic process
- cellular response to oxidative stress
- negative regulation of translational initiation in response to stress
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- response to nutrient levels
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- dendrite membrane
- nucleus
- centrosome
- cytoplasm
- nuclear speck
- cytosol
- macromolecular complex
- nuclear periphery
- neuron projection
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cAMP response element binding protein binding
- protein kinase binding
- identical protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- leucine zipper domain binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- protein heterodimerization activity