Hmgcr Gene Summary [Mouse]
Enables GTPase regulator activity and hydroxymethylglutaryl-CoA reductase (NADPH) activity. Involved in negative regulation of amyloid-beta clearance; negative regulation of protein catabolic process; and negative regulation of protein secretion. Acts upstream of or within several processes, including long-term synaptic potentiation; regulation of MAPK cascade; and visual learning. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane and peroxisomal membrane. Is expressed in several structures, including autopod; branchial arch; central nervous system; ganglia; and heart valve. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; coronary artery disease (multiple); diabetes mellitus (multiple); muscular disease (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hmgcr |
| Official Name | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [Source:MGI Symbol;Acc:MGI:96159] |
| Ensembl ID | ENSMUSG00000021670 |
| Bio databases IDs | |
| Aliases | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase |
| Synonyms | 3H3M, 3-hydroxy-3-methylglutaryl-CoA reductase, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase, 3-Methylglutaryl Coenzyme A Reductase, Hmg, HMG-CoAR, HMG-CoA reductase, HMGR, HYDROXYMETHYLGLUTARYL-COENZYME A REDUCTASE, LDLCQ3, LGMDR28, MYPLG, Red |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hmgcr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)
- GTPase regulator
- catalytic domain
- protein phosphatase binding
- enzyme
- protein binding
- identical protein binding
- hydroxymethylglutaryl-CoA reductase
- Hydroxymethylglutaryl-coenzyme A reductase
- NADPH binding
- hydroxymethylglutaryl-CoA reductase (NADPH2)
- binding protein
- transmembrane domain
- Hydroxymethylglutaryl-CoA reductase family
- Sterol-sensing domain of SREBP cleavage-activation
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase
- sterol sensing domain
Pathways
Biological processes and signaling networks where the Hmgcr gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- Crohn disease
- asthma
- uveitis
- multiple sclerosis
- psoriasis
- inflammatory bowel disease
- systemic lupus erythematosus
- proteinuria
- stroke
role in cell
- phosphorylation in
- expression in
- production in
- morphology
- proliferation
- activation in
- migration
- apoptosis
- growth
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- endoplasmic reticulum mitochondria contact site
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- microsome
- peroxisome membrane
- outer nuclear membrane
- nuclear envelope
- peroxisomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hmgcr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of ERK1 and ERK2 cascade
- negative regulation of protein secretion
- cholesterol biosynthetic process
- negative regulation of beta-amyloid clearance
- negative regulation of protein catabolic process
- coenzyme A metabolic process
- long-term synaptic potentiation
- visual learning
- isoprenoid biosynthetic process
- sterol biosynthetic process
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- NADPH binding
- GTPase regulator activity
- hydroxymethylglutaryl-CoA reductase (NADPH) activity