Itpkc Gene Summary [Mouse]
Enables inositol-1,4,5-trisphosphate 3-kinase activity. Predicted to be involved in cellular response to calcium ion; inositol phosphate biosynthetic process; and phosphatidylinositol phosphate biosynthetic process. Predicted to be located in nuclear speck. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including blastocyst and early embryo. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human ITPKC (inositol-trisphosphate 3-kinase C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itpkc |
| Official Name | inositol 1,4,5-trisphosphate 3-kinase C [Source:MGI Symbol;Acc:MGI:2442554] |
| Ensembl ID | ENSMUSG00000003752 |
| Bio databases IDs | |
| Aliases | inositol 1,4,5-trisphosphate 3-kinase C |
| Synonyms | 9130023N17RIK, inositol 1,4,5-trisphosphate 3-kinase C, inositol-trisphosphate 3-kinase C, IP3-3KC, IP3K-C |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Itpkc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- inositol-trisphosphate 3-kinase
- Inositol polyphosphate kinase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Itpkc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inositol phosphate biosynthetic process
- cellular response to calcium ion
- phosphatidylinositol phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calmodulin binding
- inositol-1,4,5-trisphosphate 3-kinase activity
- inositol tetrakisphosphate kinase activity