Aurka Gene Summary [Mouse]
Enables histone H3S10 kinase activity and ubiquitin protein ligase binding activity. Acts upstream of or within several processes, including microtubule cytoskeleton organization; positive regulation of oocyte maturation; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in axon hillock; microtubule cytoskeleton; and nucleus. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including alimentary system; bone; brain; eye; and genitourinary system. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian cancer; and uterine cancer. Orthologous to human AURKA (aurora kinase A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aurka |
| Official Name | aurora kinase A [Source:MGI Symbol;Acc:MGI:894678] |
| Ensembl ID | ENSMUSG00000027496 |
| Bio databases IDs | |
| Aliases | aurora kinase A |
| Synonyms | AIK, AIRK1, ARK-1, AURA, AURORA 2, AURORA A, aurora A kinase, AURORA KINASE, aurora kinase A, Aurora Related Kinase1, Ayk1, BTAK, IAK, IAK1, PPP1R47, STK15, STK6, STK7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aurka often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- protein serine/threonine kinase
- protein threonine/tyrosine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- protein kinase binding
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- PP1 binding domain
- enzyme
- protein binding
- Protein kinase domain
- aurora box
- activation loop
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Kinase-like
- Tyrosine kinase, catalytic domain
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Aurka gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- tumorigenesis
- lung cancer
- epithelial cancer
- neoplasia
- acute myeloid leukemia
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- prostate cancer
- liver cancer
role in cell
- quantity
- generation in
- cell death
- phosphorylation in
- expression in
- transactivation in
- production in
- glycolysis in
- growth
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- microtubule cytoskeleton
- spindle apparatus
- Cytoplasm
- perinuclear region
- basal bodies
- centrosome
- centriole
- microtubules
- midbody
- asters
- microtubule organizing centers
- cytosol
- basolateral membrane
- nucleoplasm
- spindle pole
- spindle fibers
- pronucleus
- germinal vesicles
- axon hillock
- synaptosomes
- synapse
- mitotic spindle
- meiotic spindles
- centromeres
- perikaryon
- postsynaptic density
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aurka gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spindle organization
- positive regulation of oocyte maturation
- mitotic spindle organization
- response to wounding
- protein autophosphorylation
- positive regulation of mitosis
- spindle assembly involved in female meiosis I
- protein phosphorylation
- negative regulation of protein binding
- mitotic cell cycle
- centrosome localization
- cell division
- anterior/posterior axis specification
- chromatin remodeling
- G2/M transition of mitotic cell cycle
- apoptotic process
- regulation of cytokinesis
- protein localization to centrosome
- mitotic centrosome separation
- positive regulation of mitochondrial fission
- regulation of centrosome cycle
- positive regulation of mitotic cell cycle
- negative regulation of gene expression
- proteasomal ubiquitin-dependent protein catabolic process
- regulation of protein stability
- negative regulation of apoptotic process
- peptidyl-serine phosphorylation
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- microtubule cytoskeleton
- cilium basal body
- germinal vesicle
- kinetochore
- axon hillock
- nucleoplasm
- nucleus
- spindle pole centrosome
- spindle microtubule
- centrosome
- spindle midzone
- perinuclear region of cytoplasm
- mitotic spindle
- centriole
- pronucleus
- spindle
- cytosol
- chromosome passenger complex
- meiotic spindle
- midbody
- basolateral plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase binding
- ubiquitin protein ligase binding
- protein serine/threonine/tyrosine kinase activity
- protein binding
- protein heterodimerization activity
- histone kinase activity (H3-S10 specific)
- protein kinase activity
- protein serine/threonine kinase activity