Erp44 Gene Summary [Mouse]
Predicted to enable protein disulfide isomerase activity. Predicted to be involved in several processes, including protein folding; response to endoplasmic reticulum stress; and response to unfolded protein. Located in cell surface. Is expressed in several structures, including heart and pericardium; jaw; and orbito-sphenoid. Orthologous to human ERP44 (endoplasmic reticulum protein 44). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Erp44 |
| Official Name | endoplasmic reticulum protein 44 [Source:MGI Symbol;Acc:MGI:1923549] |
| Ensembl ID | ENSMUSG00000028343 |
| Bio databases IDs | |
| Aliases | endoplasmic reticulum protein 44 |
| Synonyms | 1110001E24Rik, AI849526, AL033348, BWK4, endoplasmic reticulum protein 44, Kiaa0573, PDIA10, TXNDC4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Erp44 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein disulfide-isomerase
- thioredoxin-like domain
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme
- protein binding
- thioredoxin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ocular sarcoidosis
- preeclampsia
- idiopathic scoliosis
- cystic kidney disease
regulates
- Ca2+
- IgM
- ITPR1
- Myelin
- zymosan
- glycoprotein
role in cell
- phagocytosis
- phagocytosis by
- polymerization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- endoplasmic reticulum mitochondria contact site
- secretory granule lumen
- cell surface
- Extracellular Space
- Nucleus
- Golgi Apparatus
- ER-to-Golgi intermediate compartment
- cytosol
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Erp44 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycoprotein metabolic process
- cell redox homeostasis
- protein folding
- response to unfolded protein
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- extracellular vesicular exosome
- specific granule lumen
- endoplasmic reticulum-Golgi intermediate compartment
- extracellular region
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein disulfide isomerase activity