Stx17 Gene Summary [Mouse]
Predicted to enable SNAP receptor activity; SNARE binding activity; and enzyme binding activity. Predicted to be involved in several processes, including autophagosome maturation; endoplasmic reticulum to Golgi vesicle-mediated transport; and endoplasmic reticulum-Golgi intermediate compartment organization. Predicted to act upstream of or within protein localization to phagophore assembly site. Located in autophagosome. Is expressed in adrenal cortex. Orthologous to human STX17 (syntaxin 17). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stx17 |
| Official Name | syntaxin 17 [Source:MGI Symbol;Acc:MGI:1914977] |
| Ensembl ID | ENSMUSG00000061455 |
| Bio databases IDs | |
| Aliases | syntaxin 17 |
| Synonyms | 4833418L03Rik, 6330411F21Rik, 9030425C21RIK, FLJ20651, LOC102724685, LOC252853, syntaxin 17 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stx17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- SNAP receptor
- protein kinase binding
- protein phosphatase binding
- Helical region found in SNAREs
- transmembrane domain
- glycine zipper domain
- protein binding
- SNARE motif
Pathways
Biological processes and signaling networks where the Stx17 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- Duchenne muscular dystrophy
- insomnia
- alopecia areata
role in cell
- survival
- accumulation
- binding in
- membrane fusion
- fusion
- organization
- survival in
- temozolomide resistance
- docking
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum mitochondria contact site
- autophagosomal membrane
- cellular membrane
- Mitochondria
- ER-to-Golgi intermediate compartment
- cytosol
- endoplasmic reticulum membrane
- lysosome membrane
- autophagic vacuoles
- transport vesicles
- smooth endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stx17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endoplasmic reticulum-Golgi intermediate compartment organization
- ER to Golgi vesicle-mediated transport
- protein localization to pre-autophagosomal structure
- vesicle fusion
- vesicle docking
- Golgi organization
- autophagic vacuole docking
- intracellular protein transport
- exocytosis
Cellular Component
Where in the cell the gene product is active
- rough endoplasmic reticulum
- ER-mitochondrion membrane contact site
- endoplasmic reticulum-Golgi intermediate compartment
- plasma membrane
- autophagic vacuole
- autophagic vacuole membrane
- lysosomal membrane
- endoplasmic reticulum membrane
- smooth endoplasmic reticulum membrane
- mitochondrion
- ER to Golgi transport vesicle membrane
- endomembrane system
- cytosol
- SNARE complex
- ER to Golgi transport vesicle
- HOPS complex
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- protein phosphatase binding
- SNAP receptor activity
- SNARE binding